Colonic absorption of salmon calcitonin using tetradecyl maltoside (TDM) as a permeation enhancer
نویسندگان
چکیده
منابع مشابه
Evaluation of salmon calcitonin (sCT) enteric-coated capsule for enhanced absorption and GI tolerability in rats.
BACKGROUND Considering the chronic and repeated nature of salmon calcitonin (sCT) therapy, the oral route is a preferred route of administration. But, the oral bioavailability of sCT is very low due to enzymatic degradation and poor permeation across intestinal epithelial cells. It was the aim of this study to investigate the pharmacodynamic (PD), pharmacokinetic (PK), and mucosal injury charac...
متن کاملVascular and Renal Actions of Salmon Calcitonin
When freshwater eels were given either 5 or 15 i.u. calcitonin kg" body weight, there was an increase in dorsal aortic blood pressure as well as a rise in urine volume, glomerular filtration rate and electrolyte excretion rate, 1 h after injection. None of these changes was shown by seawater-adapted eels. When freshwater-adapted eels received 15 i.u. calcitonin kg" body weight there were signif...
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A two-site assay was developed by use of the "dissociation and enhancement lanthanide fluoroimmunoassay" (DELFIA) technique for determination of salmon calcitonin (SCT) in serum after administration to osteoporotic patients. Polyclonal antibodies were produced in rabbits immunized with SCT coupled to ovalbumin. After affinity purification, the antibodies were used both as immobilized capture an...
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The therapeutic activity of peptides or protein drugs is highly dependent on their conformational structure. The protein structure is flexible and responds to external conditions, which may compromise the protein’s native conformation and influence its physical and chemical stability. The physical and chemical stability of peptides or protein drugs are important characteristics of biopharmaceut...
متن کاملTransdermal Drug Delivery with Permeation Enhancer
Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics model of drug diff...
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ژورنال
عنوان ژورنال: European Journal of Pharmaceutical Sciences
سال: 2013
ISSN: 0928-0987
DOI: 10.1016/j.ejps.2013.01.009